Kannan Muthu

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Ph.D. Bioinformatics
31 years old
Structural Bioinformatics, Bio-molecular simulation, Protein Purification and Crystallization
  1. Nishith Saurav Topno, Muthu Kannan and Ramadas Krishna. Mechanistic insights into the activity of Ptf1-p48 (Pancreas Transcription factor 1a): Probing the interactions levels of Ptf1-p48 with E2A-E47 (Transcription factorE2-alpha) and ID3 (Inhibitor of DNA binding 3). Journal of Biomolecular Structure and Dynamics (2017). Accepted Manuscript. DOI: http://dx.doi.org/10.1080/07391102.2017.1336487. (IF: 2.3) (API Score:14 ) [ISSN: 0739-1102] (SCI)

  2. Mirza S. Baig, Kannan Muthu, Anjali Roy , Mansi Srivastav, Uzma Saqib, Adnan Naim, Rohit Saluja, Dongfang Liu. Heterotrimeric complex of p38 MAPK, PKCδ, and TIRAP is required for AP1 mediated inflammatory response. International Immunopharmacology 48 (2017) 211–218. (IF: 2.55) (API Score:14 ) [ISSN: 1567-5769] (SCI)

  3. Yellamandayya Vadlamudi, Kannan muthu, Suresh Kumar M. Structural exploration of acid sphingomyelinase at different physiological pH through molecular dynamics and docking studies. RSC Adv., 2016, 6, 74859-74873, DOI: 1039/C6RA16584B. (IF: 3.84) (API Score:18 ) [ISSN: ISSN 2046-2069] (SCI)
  4. Kannan Muthu, Manivel Panneerselvam, Nishith Saurav Topno and Krishna Ramadas. Structural transition of ETS1 from auto-inhibited to functional state upon association with p16INK4a native and mutated promoter region. RSC Adv., 2016,6, 15960-15975, DOI: 10.1039/C5RA24525G. (IF: 3.84) (API Score:21 ) [ISSN: ISSN 2046-2069] (SCI)
  5. Kannan Muthu, Manivel Panneerselvam, Nishith Saurav Topno, Manikandan Jayaraman, Krishna Ramadas. Structural perspective of ARHI mediated inhibition of STAT3 signaling: An insight into the inactive to active transition of ARHI and its interaction with STAT3 and importinβ. Cellular Signalling. 27 (2015) 739–755; DOI: 10.1016/j.cellsig.2014.11.036 (IF: 4.47) (API Score: 21) [ISSN: 0898-6568] (SCI)
  1. Kannan M, Manivel P, Muthukumaran J, Nishith saurav topno, Aridam Atanu Das and Krishna R. Structural insights into interacting mechanism of ID1 protein with an antagonist ID1/3-PA7 and agonist ETS-1 in treatment of ovarian cancer: Molecular Docking and Dynamics studies. J Mol Model. (2012) 18:4865–4884. DOI: 10.1007/s00894-012-1489-x (IF: 1.87) (API Score:18 ) [ISSN: 1610-2940 (Print) 0948-5023 (Online)] (SCI)
  1. Kannan, M., Amit Goyal, Manivel, P., Anil Kumar Pole & Krishna, R.
    Molecular dynamics simulation of the Staphylococcus aureus YsxC protein: molecular insights into ribosome assembly and allosteric inhibition of the protein.J Mol Model. (2011) 17:3129–3149 . DOI 10.1007/s00894-011-0998-3 (IF: 1.87) (API Score:12 ) [ISSN: 1610-2940 (Print) 0948-5023 (Online)] (SCI)
  1. Kannan, P. Manivel , K. Geetha, J. Muthukumaran, H. Surya Prakash Rao and R. Krishna. Synthesis and in silico evaluation of 1N-methyl-1S-methyl-2-nitroethylene (NMSM) derivatives against Alzheimer disease: to understand their interacting mechanism with Acetylcholinesterase. Journal of Chemical Biology . 2012,  5:151–166 (DOI 10.1007/s12154-012-0084-z) (IF: 0) (API Score:12 ) [ISSN: 1864-6158 (Print) 1864-6166 (Online)] (Non-SCI)
  1. Manivel Panneerselvam, Kannan Muthu and Krishna Ramadas. Structural insights into tumor-specific chaperoning activity of gamma synuclein in protecting estrogen receptor alpha 36 and its role in tamoxifen resistance in breast cancer. Molecular BioSystems 2015 Nov;11(11):2998-3010 DOI: 10.1039/c5mb00272a. (IF: 3.35) (API Score:14 ) [ISSN: 1742-2051] (SCI)
  1. M Tharaheswari, N Jayachandra Reddy, R Kumar, K C Varshney, M Kannan, S Sudha Rani: Trigonelline and diosgenin attenuate ER stress, oxidative stress-mediated damage in pancreas and enhance adipose tissue PPARγ activity in type 2 diabetic rats.. Molecular and Cellular Biochemistry. (2014) 396:161–174. (IF: 2.39) (API score: 12) [ISSN: 0300-8177 (Print) 1573-4919 (Online)] (SCI)
  1. Anand Thirunavukarasou, Gokulapriya Govindarajalu, Prachi Singh, Venkateshwarlu Bandi, Kannan Muthu and Sudhakar Baluchamy. Cullin 4A and 4B ubiquitin ligases interact with γ-tubulin and induce its polyubiquitination. Molecular and Cellular Biochemistry. 12/2014; 401(1-2) 219-28. (IF: 2.39) (API score: 12) [ISSN: 0300-8177 (Print) 1573-4919 (Online)] (SCI)
  1. Nishith Saurav Topno, Muthu Kannan, Ramadas Krishna. Interacting mechanism of ID3 HLH domain towards E2A/E12 transcription factor-An insight through molecular dynamics and docking approach. Biochemistry and Biophysics Reports 5(2016)180–190. (IF: 0) (API Score:8 ) [ISSN: 2405-5808] (Non- SCI)
  2. Manivel P, Kannan M, Muthukumaran J, Upasana S, Pranitha J and Krishna R. Molecular dynamic simulations of the tubulin–human gamma synuclein complex: structural insight into the regulatory mechanism involved in inducing resistance against Taxol. Molecular BioSystems. 2013, 9, 1470—1488. DOI: 10.1039/c3mb25427e (IF: 3.35) (API Score:14 ) [ISSN: 1742-2051] (SCI)
  1. Manikandan Jayaraman, Rajarathinam Balakrishnan, Kannan Muthu, Manivel Panneerselvam, Vasuki Gnanasambandam, Krishna Ramadas: Crystallographic and DFT Studies on Pyrrolo[1,2-c]imidazole Scaffolds. Journal of Crystallography. 04/2014; Volume 2014:8. (IF: 0) (API Score: 8 ) [ISSN:] (Non-SCI)
  1. AT Ajao, M Kannan, R Krishna, SE Yakubu, VJ Umoh & JB Ameh. Homology modeling, simulation and molecular docking studies of catechol-2, 3-Dioxygenase from Burkholderia cepacia: Involved in degradation of Petroleum hydrocarbons. Bioinformation 8(18): 848-854 (2012). (IF: 0.5) (API Score:8 ) [ISSN: 0973-2063] (Non-SCI)
  1. Muralikrishna, M. Kannan, V. Padmavathi, A. Padmaja and R. Krishna. N-(4-Chlorophenyl)-1-(5-{[(2-phenylethenyl) sulfonyl]methyl}-1,3,4- oxadiazol-2-yl)methanesulfonamide. Acta Cryst. (2012). E68, o2954 (IF: 0.35) (API Score: 8) [ISSN: 1600-5368] (Non-SCI)
  2. Manivel, P., Muthukumaran, J., Kannan, M.& Krishna, R. Insight into residues involved in the structure and function of the breast cancer associated protein human gamma synuclein (2011).J Mol Model 17:251-263. DOI 10.1007/s00894-010-0718-4 (IF: 1.87) (API Score: 12) [ISSN: 1610-2940 (Print) 0948-5023 (Online)] (SCI)
  3. Muthukumaran, P. Manivel, M. Kannan, J. Jeyakanthan and R. Krishna. A framework for classification of antifreeze proteins in over wintering plants based on their sequence and structural features (2011), Journal of Bioinformatics and Sequence Analysis, 3(4), 70-88. (IF: 0) (API Score:8 ) [ISSN: 2141-2464] (Non-SCI)
  1. Muthukumaran, J., Parthiban, A., Kannan, M., Rao, H. S. P. & Krishna, R. (2011). 6,8-Dichloro-N-methyl-3-nitro-4-nitromethyl-4H-chromen-2-amine. Acta Cryst. E67, o898-o899. (IF: 0.35) (API Score:8 ) [ISSN: 1600-5368] (Non-SCI)
  1. Topno, N. S., Kumaravel, K., Kannan, M., Vasuki, G. & Krishna, R. (2011). 6-Amino-3,4-dimethyl-4-phenyl-2H,4H-pyrano[2,3-c]pyrazole-5-carbonitrile. Acta Cryst. E67, o956. (IF: 0.35) (API Score:8 ) [ISSN: 1600-5368] (Non-SCI)
  1. Muthukumaran, J., Kannan, M., Vanitha, A., Manimaran, B. & Krishna, R. (2010). Bis(-phenyltellurido-2Te:Te)bis[tetracarbonylrhenium(I)] Acta Cryst. E66, m558-m559. (IF: 0.35) (API Score: 8) [ISSN: 1600-5368] (Non-SCI)
  1. Kannan, M., Kumaravel, K., Vasuki, G. & Krishna, R. (2010). Ethyl 6-amino-5-cyano-2,4-bis(4-methylphenyl)-4H-pyran-3-carboxylate. Acta Cryst. E66, o2536. (IF: 0.35) (API Score:12 ) [ISSN: 1600-5368] (Non-SCI)
  1. Kannan, M., Manivel, P., Sarathbabu, M., Sathishkumar, R., Surya Prakash Rao, H. & Krishna, R. (2010). 3-Benzyl-6-benzylamino-1-methyl-5-nitro-1,2,3,4-tetrahydropyrimidine. Acta Cryst. E66, o515. (IF: 0.35) (API Score: 12) [ISSN: 1600-5368] (Non-SCI)
  1. Kannan, M., Kumaravel, K., Vasuki, G. & Krishna, R. (2010). Ethyl 2-(6-amino-5-cyano-3,4-dimethyl-2H,4H-pyrano[2,3-c]pyrazol-4-yl)acetate. Acta Cryst. E66, o1242. (IF: 0.35) (API Score:12 ) [ISSN: 1600-5368] (Non-SCI)
  1. Muthukumaran, P. Manivel, M. Kannan, J. Jeyakanthan and R. Krishna. Advancement in computational analysis methods of plant antifreeze proteins (AFPs): An application towards classification and gene expression studies of leucine rich repeat (LRR) and ice-recrystallization inhibition domain (IRI) containing AFPs (2011), Journal of Computational Biology and Bioinformatics Research, Vol. 3(6), pp. 65-82. (IF: 0) (API Score: 8) [ISSN: 2141-2227] (Non-SCI)
  1. Om P S, Archana P, S. L. Hoti, Ankush J, M Kannan, Premendu P. Mathur. Modeling, docking, simulation, and inhibitory activity of the benzimidazole analogue against b-tubulin protein from Brugia malayi for treating lymphatic filariasis. Chem. Research. (2012) 21:2415–2427. DOI 10.1007/s00044-011-9763-5. (IF: 1.61) (API Score: 12) [ISSN: 1054-2523 (Print) 1554-8120 (Online)] (SCI)

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